• Current therapeutic protocols in OS and ES consist

  2019-07-02

  

  Current therapeutic protocols in OS and ES consist of neoadjuvant chemotherapy and local surgical resection, followed by adjuvant chemotherapy. These treatments lead to a 70% overall survival for localized disease but can decrease to 15% in case of metastasis. With CS being resistant to conventional

• Cytidine 5-triphosphate of It is well known that acrolein

  2019-07-02

  

  It is well known that acrolein, a metabolite of cyclophosphamide, is responsible for the cyclophosphamide-induced cystitis, and that acrolein is capable of activating TRPA1 channels expressed in the capsaicin-sensitive primary afferents [2], [11]. In this context, it is likely that the early phase o

• Through an unknown mechanism RING Ubox type E

  2019-07-02

  

  Through an unknown mechanism, RING/Ubox-type E3 dimers and the N-terminal tail have been shown to function as a modulator of full E3 ubiquitin ligase activity [27]. LRSAM1 promotes a significant enhancement in the formation of the high-molecular-weight products or E3 activity when the RING domain is

• The BMP family comprises significant growth factors for the

  2019-07-02

  

  The BMP family comprises significant growth factors for the regeneration of bone and cartilage. Among these, BMP- has been known as an early marker during the proliferation of osteoblast cells, and one of the most potent stimulators of osteoblastic cells differentiation [40]. Studies with COX-2 knoc

• br After several decades of

  2019-07-01

  

  After several decades of community-based interventions and surveillance, on Nov 15, 2016, Morocco was recognised by WHO as having eliminated trachoma as a public health problem. A formal ceremony, involving the handover of a letter of recognition from Margaret Chan, WHO\'s Director-General, marked

• br Conflict of interest br Introduction br

  2019-07-01

  

  Conflict of interest Introduction Baseline ablation strategies targeting PVs It is well known that PVI was first developed to eliminate the triggers that initiate attacks of paroxysmal atrial fibrillation [1]. Subsequently, the additional function of the PV myocardium to perpetuate atrial f

• Cisplatin based chemotherapy is commonly used in adjuvant CC

  2019-07-01

  

  Cisplatin-based chemotherapy is commonly used in adjuvant CCRT, but data on carboplatin-based chemotherapy with radiotherapy is lacking. Khoury et al reported that patients treated with carboplatin-based chemoradiotherapy show worse outcomes. However, the impact on patient comorbidities was not repo

• br Bone half life based dosing As zoledronic

  2019-07-01

  

  Bone half-life based dosing As zoledronic ack1 inhibitor has been shown to have anti-tumor efficacy in both the pre-clinical and clinical settings using the conventional regimen (zoledronic acid 4mg infusion 4 weekly), some studies were designed to explore the anti-tumor effects of zoledronic ac

• Myosmine weight The majority of breast malignancies are horm

  2019-07-01

  

  The majority of breast malignancies are hormone responsive, and adjuvant endocrine therapy is used routinely to prevent breast cancer recurrence and death [6,7]. Tamoxifen was the past treatment of choice for endocrine-responsive postmenopausal breast cancer and was found to preserve BMD in postmeno

• Desde aqu partiremos para apreciar las virtudes de

  2019-07-01

  

  Desde aquí partiremos para apreciar las virtudes de la perspectiva de Villoro en la defensa de la diversidad cultural frente a la postura de Garzón Valdés, Villoro señala que el problema de la diversidad cultural no está en la ponderación de la superioridad técnica de la cultura mayoritaria, sino en

• INTRODUCCI N Nuestra hip tesis general es que durante

  2019-07-01

  

  INTRODUCCIÓN Nuestra hipótesis general es que durante el periodo 1982-1985 se constituyó en Guatemala una dictadura institucional fundacional de las fuerzas armadas similar what is doxycycline hyclate la experiencia de Argentina (1976-1983), y que parte de esas semejanzas se deben, entre otras razo

• In an earlier study we used a questionnaire to

  2019-07-01

  

  In an earlier study, we used a questionnaire to assess musculoskeletal pain in patients with CML who had achieved DMR (MR4.0) and discontinued TKI treatment, including IM, nilotinib, and dasatinib [5]. Nine out of the 27 patients surveyed developed musculoskeletal pain after discontinuing TKIs. In t

• Chronic hepatitis B virus HBV infection is prevalent

  2019-06-29

  

  Chronic PluriSIn #1 weight virus (HBV) infection is prevalent in many Asian countries, notwithstanding three decades of universal hepatitis B vaccination programs. The invention of nucleos(t)ide analogs (NUCs) was a breakthrough in the treatment of chronic hepatitis B (CHB). However, HBV continues t

• br Commentary The concept of entrainment mapping for ablatio

  2019-06-29

  

  Commentary The concept of entrainment mapping for ablation of VT is that targeting the site will interrupt the reentrant VT circuit. This site must be located, not only within the circuit, but also in a protected and relatively narrow isthmus. During entrainment mapping, the QRS morphology, S-QRS

• br Discussion Studies have reported that permanent

  2019-06-29

  

  3. Discussion Studies have reported that permanent PMI using the conventional pectoral approach is impossible or contraindicated in 1–6% of patients [1–5]. In such patients, PMI via the iliac vein is considered an effective alternative. The advantages of this approach are that the wound size and

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