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Mulan is a mitochondrial protein and is
2020-02-04
Mulan is a mitochondrial protein and is exclusively localized in the OMM with its RING domain facing the cytosol [14]. Based on this topology, Mulan can provide a link between molecular events in the mitochondria and cytoplasm. Mulan has been implicated in various processes including: mitochondrial
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The fact that the mean tumor size
2020-02-04
The fact that the mean tumor size of the E1202-654 + α-GalCer group was much smaller than that of the α-GalCer inoculated group in both protocols indicates that immunization with E1202-654 plus α-GalCer, which induces a strong CD8+ T cell E1 antigen-specific immune response, is involved in the elimi
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To date many studies have reported significant aberrant
2020-02-04
To date, many studies have reported significant aberrant methylation patterns in TIMPs in various types of cancer Necrostatin 1 [[16], [17], [18]]. However, little has been reported on the events that lead to the methylation of TIMPs in the UV-irradiated human skin. Therefore, the objective of this
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In a previous study we reported that the systemic administra
2020-02-04
In a previous study we reported that the systemic administration of the α1-adrenergic receptor antagonist prazosin attenuates the deficit in GDC-0834 reward function associated with precipitated nicotine withdrawal (Bruijnzeel et al., 2010). One of the aims of the present experiments was to investi
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br Next let s recall some definitions and notations
2020-02-04
Next, let\'s recall some definitions and notations from [14] which are necessary to obtain the proof of Theorem 1. Let denote the CMV matrix whose Verblunsky coefficients replaced by , that is The corresponding extended CMV matrix is Recall the definition of in the proof of Theorem 2, replace
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Brilliant Blue G br Study design br Results We enrolled subj
2020-02-03
Study design Results We enrolled 50 subjects awaiting SOT (15 kidney, 14 liver, 1 liver + small bowel, 11 lung, 9 heart) and 50 controls (Table 1) who were similar with respect to median age (subjects 49.1 yrs., controls 48.6 yrs.) gender (64% male subjects and controls), and CMV-seropositivit
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br Structure of USP Schematic representation of
2020-02-03
Structure of USP7 Schematic representation of the USP7 domain architecture is shown in Fig. 3B. USP7 is a 135 kDa protein that consists of seven domains, including the N-terminal TRAF-like (Tumor necrosis factor Receptor–Associated Factor) domain, followed by the catalytic core domain and the fiv
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In mammals neutrophil elastase is a trypsin
2020-02-03
In mammals, neutrophil elastase is a trypsin-like serine protease stored in the azurophilic granules of naïve neutrophils [15], [16]. The catalytic activity of neutrophil elastase relies on a His57–Asp102–Ser195 triad (chymotrypsin numbering system) that functions by transfer of electrons from the c
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Indeed some cancers may even
2020-02-03
Indeed, some cancers may even be defined by dysregulated cyclin and thus CDK activity: mantle cell lymphoma, an uncommon lymphoma of mature B cells, is defined by the presence of overexpressed cyclin D1, usually as a result of a translocation between chromosomes 11 and 14 with the net result that c
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To evaluate the new quadrupolar CPA qCPA the pure fluid
2020-02-03
To evaluate the new quadrupolar CPA (qCPA) the pure fluid properties of CO2 are predicted both in the critical region and in the compressed liquid region. The model is furthermore applied for the prediction and correlation of binary mixtures with CO2 and n-alkanes, water, alcohols and a few quadrupo
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Phenylbenzofurans are a very important molecule
2020-02-03
Phenylbenzofurans are a very important molecule skeleton due to their synthetic versatility and their proved pharmacological properties [2]. They are synthetic compounds in which an additional phenyl ring is present in any position of the benzofuran nucleus. This could be easily obtained possible by
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calpain inhibitor 1 Finally naringin and hesperidin have
2020-02-03
Finally, naringin and hesperidin have different glycosidic moieties (neohesperidose α-1,2 and rutinose α-1,6 respectively), bound in the same C7 position on the A ring of the flavonoid. The higher value of k/KM of RHA-Phis towards the former substrate suggests that the enzyme shows a preferential hy
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br Activatable photoacoustic probes Photoacoustic PA imaging
2020-02-03
Activatable photoacoustic probes Photoacoustic (PA) imaging is a recently developed technique [47]. The imaging approach uses probes that absorb a pulsed laser beam and convert light energy into acoustic signals. It combines the advantages of the high sensitivity offered by optical imaging and th
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ApoE is secreted from astrocytes glia into the interstitial
2020-02-03
ApoE is secreted from astrocytes/glia into the interstitial fluid and is important for metabolizing Aβ because of its propensity for binding Aβ as a cholesterol and phospholipid acceptor in reverse cholesterol transport [8]. Aβ oligomers show a direct toxicity to neurons, and ApoE inhibits oligomer
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Interestingly we observed that T D islet cells have
2020-02-03
Interestingly, we observed that T2D islet azd6244 have lower DPP-4 expression, as compared to ND cells (Fig. 1, Fig. 2). Previously, a reduced activity of this peptidase was observed in human T2D islet lysates (Omar et al., 2014). As mentioned above, GLP-1 is also produced by islet cells (alpha cel
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