• According to Graeff Graeff innate fear is mediated

  2020-08-05

  

  According to Graeff (Graeff, 1990), innate fear is mediated by neural circuitry that consists of at least the amygdala, medial hypothalamus and periaqueductal grey matter. In particular, the BLA has been considered to be a structure closely related to emotional responses to fear, stress and anxiety

• Clinical studies have shown that the degree of metabolic alt

  2020-08-05

  

  Clinical studies have shown that the degree of metabolic alteration varied by type and dose of the progestogen component [13] and that the higher androgenic formulations consistently had the strongest effects [14], [15]. Although, our finding that high dose progestogen-containing combined OC produce

• To gather more insights into the catalytic mechanism

  2020-08-05

  

  To gather more insights into the catalytic mechanism of RHA-Phis for a future fine-tuning of this biotechnologically relevant enzyme, a combined approach of sequence alignment and homology modeling was used. The alignment of RHA-P sequence with 130 homologs of the GH106 family allowed identifying fi

• br Data availability br Acknowledgments The work was

  2020-08-04

  

  Data availability Acknowledgments The work was supported in Department of Biochemistry by grants from British Heart Foundation (SP/15/7/31561, FS/15/20/31335 and RG/15/4/31268). At the Department of Materials Science, Cambridge, funding was from the People Programme of the EU 7th Framework Pro

• The first step in the biosynthesis of

  2020-08-04

  

  The first step in the biosynthesis of steroid hormones is the translocation of cholesterol into the inner mitochondrial membrane, a process regulated by the steroidogenic acute regulatory protein STARD1 (also known as StAR), which is believed to act as a shuttle enzyme (Miller & Strauss, 1999). This

• The production of papaya and pineapple around the

  2020-08-04

  

  The production of papaya and pineapple around the world, is characterized by generating a volume of waste close to 25% for papaya (seeds and peels) and 50% for pineapple (Ketnawa et al., 2012, Ordoñez et al., 2016), not counting the harvest surpluses and the rejected fruits (green and ripe). In Colo

• The rate of protein degradation

  2020-08-04

  

  The rate of protein degradation is often affected by N-starvation [12], therefore, we examined the influence of N-starvation against the appearance of CEPs. N-starved cucumber cotyledons contained less amounts of protein and Rubisco, but the temporal changes in protein and Rubisco contents were sim

• Introduction Collagen fibrillogenesis the assembly of collag

  2020-08-04

  

  Introduction Collagen fibrillogenesis, the assembly of collagen fibers, is a critical process in the development, maturation, and repair of mammalian tissue. Alterations in the structure and amount of deposited collagen fibers can greatly alter the integrity of the whole tissue. Even a single point

• br Acknowledgements br Introduction As

  2020-08-04

  

  Acknowledgements Introduction As our knowledge and understanding of the species differences in the regulation and substrate specificity of the mammalian CYP450 JC-1 australia has broadened significantly, the need for a human-relevant in vitro hepatic model system has become more apparent than

• The incretin hormones such as GLP are major regulators

  2020-08-04

  

  The incretin hormones, such as GLP-1, are major regulators of post-prandial insulin secretion, and DPP-4 cleaves the incretin hormones [4]. It has been reported that Plg can interact with DPP-4 [5]. Next, we showed that Plg deficiency was associated with lower DPP-4 activity, and elevated the levels

• As an initial step toward

  2020-08-04

  

  As an initial step toward this goal, we wished to study the DNA binding mode and affinity of a series of derivatives (1a–1f) of the cationic dye crystal violet (Fig. 1) [8], which can be readily prepared by addition of Grignard reagents derived from 4-bromo-N,N-dimethylaniline to diverse ethyl 4-N,N

• Identification of the A S DNA recognition sequence and

  2020-08-04

  

  Identification of the A1S_0222 DNA recognition sequence and methyltransferase activity. According to REBASE, a database in which information about restriction enzymes, DNA methyltransferases, recognition and cleavage sites, published and unpublished references are collected [50,51], the A. baumannii

• Streptomycin sulfate br Conclusions br Funding This work was

  2020-08-03

  

  Conclusions Funding This work was supported by Grant 1512-366261/758K and 961-386261/917K from the Innovation Foundation of the State of Rhineland-Palatinate, by the Collaborative Research Center SFB 553 (Project A7 to HK), and the DFG grant Li 1759/1-1 (to HK). This study was partly supporte

• br Materials and Methods br Results br Discussion Mitochondr

  2020-08-03

  

  Materials and Methods Results Discussion Mitochondrion not only generates energy but also produces ROS under physiological conditions. However, overnutrition causes mitochondrial congestion and elicits excessive ROS generation, leading to insulin resistance (Muoio, 2014, Houstis et al., 200

• Previous studies have shown the harmful effects of NEFA on

  2020-08-03

  

  Previous studies have shown the harmful effects of NEFA on ovarian functionality, such as inhibition of bovine granulosa cell survival and proliferation, steroidogenesis, and follicular development and alteration in oocyte development [36,45,46]. Therefore, the higher levels of NEFA found in the fol

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