• In young animals the HT A

  2024-07-23

  

  In young animals, the 5-HT2A ORY-1001 antagonist ketanserin, at relatively low concentrations, shifted 5-HT concentration-response curves rightward, suggesting a role for 5-HT2A receptors in mediating 5-HT-induced contractions of the ureter. The slopes of the ketanserin Schild plots for the antagon

• Because serum ATX activity and

  2024-07-22

  

  Because serum ATX activity and nociceptin receptor LPA are well correlated with liver fibrosis stage histologically, both of these parameters merit consideration as novel markers of fibrosis. However, serum ATX activity may be a more useful test from a clinical laboratory perspective. First, LPA ca

• Imatinib is a well known anticancer drug used in

  2024-07-22

  

  Imatinib is a well-known anticancer drug used in Chronic Myeloid Leukemia (CML) against the altered expression/activity of tyrosine kinase resulting from the fusion of BCR-ABL in leukemic blasts. It has been demonstrated that Imatinib can induce autophagy in BCR-ABL expressing alpha amanitin (K562

• nitric oxide synthase inhibitors Exposure to cisplatin with

  2024-07-22

  

  Exposure to cisplatin with ATR inhibitor resulted in an increase in cisplatin-DNA adducts, especially in cells with ATM deficiency. This finding indicates that suppressing ATR-Chk1 signaling with VE-822 enhances cisplatin activity by enabling the drug to form DNA adducts. Therefore, VE-822 may incre

• StemRegenin 1 synthesis br Materials and methods br Results

  2024-07-22

  

  Materials and methods Results Table 1 presents the metabolic phenotype of obese minipigs. After 60 d of HFHS feeding, minipigs not only showed an increased body weight (+45%), but also a perturbed StemRegenin 1 synthesis homeostasis, with higher insulin levels (about +2-fold), HOMA-IR (+5.5-fo

• br Introduction Adenosine deaminase ADA also known as adenos

  2024-07-20

  

  Introduction Adenosine deaminase (ADA), also known as adenosine aminohydrolase, is a key enzyme involved in the purine metabolism that converts adenosine to inosine irreversibly (Lupidi et al., 1997). It is a zinc containing metalloenzyme present in both prokaryotes and eukaryotes. In humans ADA

• br Conclusions and future directions Translation of the

  2024-07-20

  

  Conclusions and future directions Translation of the therapy to human MG will require a substitute adjuvant for IFA. Most human vaccines use aluminum salts (alum) as adjuvants. Both IFA and alum selectively promote antibody dominated Th 2 immune responses, rather than T killer cell dominated Th 1

• br Results br Discussion Dopamine

  2024-07-20

  

  Results Discussion Dopamine regulates behavioral responses to nicotine in Drosophila (Bainton et al., 2000), but neurochemical measurements of dopamine after nicotine stimulation had not been made. Here, we demonstrate for the first time that the stimulation of nAChRs causes dopamine release i

• To date more than different mutations in the

  2024-07-20

  

  To date, more than 50 different mutations in the gene have been described (Human Gene Mutation Database at the Institute of Medical Genetics in Cardiff: SRD5A2 Gene: http://www.hgmd.cf.ac.uk). Most of them are missense mutations but premature stop codons and deletions leading to non-functional or su

• As mentioned above variation of the A ring was undertaken

  2024-07-20

  

  As mentioned above, variation of the A-ring was undertaken in order to improve microsomal stability and kinase selectivity relative to BMS354825 (). 1-Imidazole-2-carboxamides with substitution at the 4-position (–) were mostly tolerated with 4-cyano-imidazole-2-carboxamide () having comparable inh

• Screening a selection of analogues from this library

  2024-07-20

  

  Screening a selection of analogues from this library against the panel of 26 kinases (16, 22, and 24 were screened at 30 μM due to poor solubility; 17 tested at 100 μM) generally demonstrated an increase in activity compared to benfotiamine mg 3 (Fig. 3, Fig. 6). The benzamide analogue 16 demonstra

• br Introduction The process of mitosis

  2024-07-20

  

  Introduction The process of mitosis is highly complex and tightly regulated. This phase of the Kasugamycin hydrochloride resulted in two identical daughter cells. The aurora kinases (aurora A, B, and C) are a family of three highly homologous serine-threonine protein kinases that play a key role

• Here we report discovery of highly selective pan

  2024-07-20

  

  Here we report discovery of highly selective pan-Aurora kinase inhibitors through phenotypic screening. The co-crystal structure of Pleuromutilin bound in the ATP binding site of Aurora A is described, and provides insight into the possible structural basis for the selectivity of the interaction.

• Hypoxia of the adipose tissue

  2024-07-20

  

  Hypoxia of the adipose tissue is a key step in the inflammatory response linked to obesity and contributes to accelerated tumor progression in the obese population (Rosenow et al., 2013). Intermittent hypoxia exposure induces a 2.2-fold increase in the infiltration of tumor-associated macrophages an

• In previous years evidence emerged that

  2024-07-20

  

  In previous years, evidence emerged that inferred secondary metabolites in plants might exhibit a potential arginase inhibition [36]. In a recent study, Pham and co-workers showed the inhibitory activity of chlorogenic IC261 (7) and piceatannol (8) (Fig. 3b) on mammalian arginase with IC50s of 10.6

15417 records 121/1028 page Previous Next First page 上5页 121122123124125 下5页 Last page